临床糖尿病杂志

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Understanding the Significance of Hyperglycaemia in the First Trimester of Pregnancy

Johanna Kuehn, Katie Wynne

Gestational Diabetes Mellitus (GDM) has short and long-term implications for both maternal and fetal health. The incidence of GDM is increasing rapidly worldwide. Universal screening and treatment of GDM from 24 weeks gestation is well-established, however, uncertainty remains regarding the diagnostic accuracy as well as risks and benefits of treatment for women diagnosed with GDM earlier in pregnancy. Evidence is established for the diagnosis of GDM in women from 24 to 32 weeks gestation, based on the HAPO study which showed a robust linear association between increasing plasma glucose levels and a range of adverse pregnancy outcomes.