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Virus-Like Particle-Based vaccines for Rift Valley Fever Virus
Robert B. Mandell and Ramon Flick
There is a clear need for a vaccine to protect humans and livestock against the devastating consequences of Rift Valley fever (RVF) virus infections. Virus-like particles (VLPs), readily generated for many viruses by expression of their structural proteins, are a safe and immunogenic vaccine platform that has been approved for use as human vaccines. Pre-clinical studies have shown that RVF VLPs are highly immunogenic and efficacious in rodent models, and thus present a promising vaccine candidate for Rift Valley fever virus.
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