营养与饮食学杂志

抽象的

An Update on Pathogenesis and Treatment of Obesity

Deepti Malik and Aman Kulvinder Kaur

With fatness having adult to epidemic proportions, nearly half girls of procreative age square measure overweight and weighty and this is often a serious public ill health. because of unfavourable sex gland stimulation protocols, higher gonadotropin consumption and poor results most insurance corporations square measure reluctant to sponsor treatment for such patients .Since diet and exercise square measure inadequate treatments and bariatric surgery perhaps too extreme, treatment within the model of alternative chronic diseases by combination therapies has prompted the event of novel combination therapies like Qysmia (topiramate/phentermine)/Contrave (Bupropion SR/Naltrexone SR) that at the same time target multiple physiological pathways that regulate energy physiological condition to overwhelm endogenous counteractive mechanisms as opposed to use of monotherapies to take care of weight loss. The sole concern is that the slight risk of teratogenicity with topiramate therefore it's higher to use birth prevention whereas victimization topiramate/bupropionSR/naltrexoneSR. In weighty diabetics the GLP-1 receptor agonists like exenatide/liraglutide stay the medication of selection in combination with endocrine, whereas combination of lixisenatide and insulinglargine square measure within the pipeline for the long run.