国际药学与生命科学研究与发展杂志

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ANALGESIC AND CNS DEPRESSANT ACTIVITY OF METHANOLIC EXTRACTS OF CISSUS VITEGENIA AND CISSUS PALLIDA

Sudha Parimala, V. Hemanth Kumar, S. M. Shanta Kumar, R. Suthakaran, A. Tamil Selvan

The main aim of the present study was to evaluate analgesic and CNS depressant activity of methanolic extracts of stem and roots of Cissus pallida and aerial parts of Cissus vitegenia in experimental animals. The analgesic activity was evaluated by Eddy’s hot plate method and CNS depressant activity was evaluated by using digital actophotometer. The study was carried out by using two different doses (200 and 400mg/kg body weight) of both the extracts. The preliminary pharmacological screening showed that both the extracts showed moderate analgesic activity and significant CNS depressant activity.