生物化学与生理学：开放获取

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Antioxidant and Anti-inflammatory Activities of Odontella aurita Aqueous Extract on Human Activated Neutrophil Granulocytes or in Stimulated Human Whole Blood

Ferdinand Kouoh Elombo, Zhen Yi Chan, Bruno ETO, Bernard Gressier, Frederic Nico Njayou, Paul Moundipa

The present study is aimed at investigating the effect of an aqueous extract of Odontella aurita (O. aurita) on oxidative-stress and inflammation. The antioxidant effects of the extract were determined throughout the inhibition of human neutrophil granulocytes generating oxygen free radicals and their by-products superoxide anion (O₂^°-) and hypochlorous acid (HOCl).  The extract was assessed for its effects on inflammation as a potential reducer of cyclo-oxygenase and lipoxygenase activities. It was found that Odontella aurita is antioxidative as inhibitor of O₂^°- and HOCl   productions. Moreover, the extract showed an Oxygen Radical Absorbance Capacity (ORAC) with a Trolox Equivalent Antioxidant Capacity of 3.55 nM comparable to that of Chlorella (3.16 nM) and Spirulina (3.60 nM). As far as anti-inflammatory activity is concerned, O. aurita inhibits the releasing of 12 HHTr marker of cyclo-oxygenase (COX 1 and COX 2) and 13 HODE marker of lipoxygenase (15 LOX 1). Based on above, Odontella aurita could be a potential candidate for healthy nutraceutical.