国际药学与生命科学研究与发展杂志

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APPROACH FOR QUANTITATIVE ESTIMATION OF EPROSARTAN MESYLATE BY UV SPECTROPHOTOMETER

Rewar S, Bansal B K, Singh C J, Sharma A K

Eprosartan Mesylate is an angiotensin II receptor (AT1) antagonist. Eprosartan Mesylate is an effective, well tolerated and potent pure competitive antagonist of the AT1 receptor and hence there has been significant research on broad range of analytical and detection techniques that could be useful in its estimation in formulations and biological matrices. A simple, sensitive and accurate UV spectrometric method has been developed for the determination of eprosartan Mesylate in raw material and experimental tablets. Beer’s law was obeyed in the concentration range 2-3μgmL-1 for the drug (=233nm) with an apparent molar absorptivity and sandell sensitivity of 2.8×104Lmol-1cm-1 and0.01854μgcm-2/0.001A, respectively. The limit of detection and quantitation were calculated to be 0.3623 and 1.098 μg mL-1, respectively. Results were validated statistically according to ICH guidelines. Validation of the method yielded good result in the concerning range (2-30μg mL-1), linearity (r2 = 0.9998), precision and accuracy. The excipients present in the experimental tablet did not interfere with the method.