生物化学与生理学：开放获取

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Changing Paradigms in Cell Biology: Their Implication and Possible Applications

Engwa Azeh Godwill

The evolution of cell biology in the 20th century has evoked some remarkable changes in the existing paradigms. The discovery of alternative splicing, overlapping genes and protein splicing has shifted the one gene-one protein paradigm to several proteins. Proteins are no more the only catalytic macromolecule since the discovery of ribozymes. Genetic material was known to be stable in the genome and not mobile until the discovery of transposons. RNA editing has made possible the identification of certain missing genes and viruses are no longer considered the smallest infections agents after prions were discovered. Though not conclusive, recent findings suggest the possibility of transcription to occur in the nucleus. All these ground breaking discoveries are making substantial breakthrough in biological sciences particularly in understanding some cellular processes, their mechanisms on gene expression and regulation as well as the pathogenesis of certain illnesses. Also, these discoveries have revealed some potential drug targets and presently, some of the implicated biomolecules are being exploited for various pharmaceutical and biomedical applications.