生物化学与生理学：开放获取

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Cytidine 5’-triphosphate Synthetase: A Pyrimidine Biosynthetic Enzyme Critical to Cellular Synthesis and Cancer Chemotherapy

Thomas P West

The pyrimidine biosynthetic enzyme Cytidine 5’-triphosphate (CTP) synthetase has an important role in the biosynthesis of RNA, DNA and phospholipids. The synthetase has been found to be highly regulated at the level of enzyme activity and enzyme synthesis in both prokaryotes and eukaryotes including humans. The enzyme has been the target of inhibition by various drugs since cellular proliferation requires CTP synthesis. The design of new drugs targetting CTP synthetase activity in humans could prove important to cancer chemotherapies since it may allow new cancer treatment procedures to be developed.