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Cytosine Deaminase: A Pyrimidine Base Salvage Enzyme Vital to the Effectiveness of a Substrate Mediated Enzyme Prodrug Chemotherapy
Thomas P West
The pyrimidine salvage enzyme cytosine deaminase occupies an important function in the effectiveness of substrate mediated enzyme prodrug chemotherapy. The basis of this chemotherapeutic approach is that cytosine deaminase can catalyze the deamination of 5-fluorocytosine to 5-fluorouracil.The resultant 5-fluorouracil formed is a radiosensitizer agent that enhances the radiological targetting of a variety of cancer cells in humans for elimination.
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