国际药学与生命科学研究与发展杂志

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Drug Utilization Evaluation of Antimicrobials in Surgical Patients in Tertiary Care Hospital

Dr. Syed Jaffer, Akif bin Sayeed, Ammar Ali Jabalpurwala, Mariam Sultana, Ummara

Drug use/utilisation is an intricate process. Wide differences in the usage of medications for any particular ailment are due to the precariousness in diagnosis, therapy, and medication adherence. Antibiotics are produced by microbes.They act by selectively suppressing the growth (bacteriostatic) of or killing (bactericidal) other microorganisms at very low concentrations. Antimicrobial agents, this term is designated for both naturally and synthetically obtained drugs that attenuate the growth of microbes. SSI is a consequence of a pathogenic microorganism multiplying in a surgical wound; it causes local and occasionally systemic signs and symptoms, which is known as a SSI. Depending on the surgical treatment and the patient, infections complicate operations in 1% to 5% of instances. SSIs are the reason for the increase in morbidity and hospital stay. Surgical Antimicrobial Prophylaxis (SAP) can be used to prevent wound infections during surgical procedures. Wound infection occurs when a crucial number of bacteria are present in the wound at the moment of closure. Antimicrobial drugs that target the invasive microorganisms can lower the no. of viable bacteria below the infection- causing threshold. The purpose of administration of SAP is to avoid or to decrease the prevalence of post-operative wound infection at or around the surgical site.