国际药学与生命科学研究与发展杂志

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EFFECT OF VITAMIN C AND VITAMIN E ON MALATHION INDUCED STRESS ON TESTICULAR TISSUE IN VITRO

R. K. Sharma and Alka Gulati

During the present investigation ameliorating effect of vitamin C and vitamin E on Malathion induced testicular toxicity has been analyzed in testis tissue of goat in vitro. Cultured testis tissue treated with three doses of Malathion concentration (1nm, 100nm, 10-3nm/ml) showed a significant decrease in antioxidants enzyme Catalase and Superoxide dismutase activites. In contrast, supplementation with vitamin C and vitamin E (100μmol/L) reduced testicular oxidative stress. These results indicate that vitamin C and vitamin E have protective roles in vitro on the Malathion induced testicular tissue in Catalase and Superoxide dismutase enzyme activities and reduce the testicular damage by Malathion. Thus, the role of vitamins C and E in amelioration Malathion induced oxidative stress has been worked out is not protective in absolute terms.