国际药学与生命科学研究与发展杂志

抽象的

NANOPARTICLES ��? AN OVERVIEW

Aarti P. Nikam, Mukesh. P. Ratnaparkhiand, Shilpa P. Chaudhari

Recently particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. They have been used in vivo to protect the drug entity in the systemic circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to the site of action.Drug delivery research is clearly moving from the micro- to the nanosize scale. Nanotechnology is therefore emerging as a field in medicine that is expected to elicit significant therapeutic benefits. The development of effective nanodelivery systems capable of carrying a drug specifically and safely to a desired site of action is one of the most challenging tasks of pharmaceutical formulation investigators. They are attempting to reformulate and add new indications to the existing blockbuster drugs to maintain positive scientific outcomes and therapeutic breakthroughs. The nanodelivery systems mainly include nanoemulsions, lipid or polymeric Nanoparticles and liposomes.For the past few years, there has been a considerable research on the basis of Novel drug delivery system, using particulate vesicle systems as such drug carriers for small and large molecules. Nanoparticles have been improving the therapeutic effect of drugs and minimize the side effects. Basically, Nanoparticles have been prepared by using various techniques as such dispersion of preformed polymers, polymerization of monomers and ionic gelation or co-acervation of hydrophilic polymer.