生物化学与生理学：开放获取

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Potential Drug Targets in the Death Pathway: Therapeutic Approaches in Apoptosis

Md. Salahuddin, Md. Shariful Islam, Abu Zaffar Shibly, Hasibul Haque Rakib, Muhammad Jahangir Hossen, Md. Ramim Tanver Rahman, MA Momin, Md. Sayfullah Razin, Jay Prakash Sah, Md. Abdur Rahman, Muhammad Aurang Zeb and Mizanur Rahman Washim

The form of programmed cell death known as Apoptosis has become an intense focus of investigation in various fields including carcinogenesis and cancer therapy. It is a sequentially regulated suicidal programme where cells regulate certain enzymes including caspase 9 activation and cytochrome C release with apoptosis inducing factor (AIF). The Bcl-2 proteins also represent a promising target for modulating tumor cell sensitivity to Apoptosis. Disturbance of this regulatory pathway may lead to various diseases like autoimmune diseases, neurodegenerative diseases and cancers. Therefore, understanding the mechanisms for apoptosis signaling pathway will give us huge knowledge to enlighten the pathogenesis of various diseases including cancer, and will open new horizons to therapeutic approaches in drug designing.