国际药学与生命科学研究与发展杂志

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PREPARATION AND COMPARATIVE CHARACTERIZATION OF DRUG RELEASE FROM TWO DIFFERENT CHRONOTHERAPEUTIC DRUG DELIVERY SYSTEMS OF SALBUTOMOL FOR NOCTURNAL ASTHMA

Papola Vibhooti Rajan G Bisht Seema Dr. Kothiyal Preeti

Coating with pH dependent polymers,based on the metabolic activity of colonic bacteria. Colonic bacteria degraded the prodrugs and polysaccharides enzymatically and then the drug releases into the colon. Previously several polysaccharides have been reported as carriers to colon-specific drug delivery. Oral compression coated tablets (CCT) compose of an inner solid core that contains an active pharmaceutical ingredient and any other pharmaceutically acceptable carriers or excipients which is substantially covered with an outer layer that dissolves or disintegrates slowly to produce the pre-determined lag time. The advantage of this manufacturing technique is that it is simple, inexpensive and it is not hazardous to the environment since it does not require the use of high amounts of organic solvents. Purpose: a) The aim of the present study was to to check the effect of chitosan on drug release and targeting it in colon by using the principle of compressed coat. b) Effect of Coating with ph independent polymer eudragit S100 on release in colon area. Method: a) Compression coated tablets of Sallbutamol were prepared by wet granulation method using chitosan and b) coating of core tablet with Eudragit S100 .