国际药学与生命科学研究与发展杂志

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ROLE OF VITAMIN D AND CALCIUM SUPPLEMENTATION IN PREGNANCY ALONE OR IN COMBINATION

Dipti Anand, Gurjit kaur, Alka Sehgal, Shikha Rani, Manju Mathur

Fetus is dependent on the mother for its nutritional need. That is why there is increased demand of nutrients in pregnancy. To meet the increased demand of calcium there are various physiological changes in calcium hemostasis. Vitamin D plays an important role in calcium hemostasis. Deficiency of vitamin D leads to various medical disorders in pregnancy and poor neonatal outcome. This study is planned to evaluate whether calcium supplementation along vitamin D has better rise calcium than calcium alone.Fifty pregnant females between 12-14 weeks were enrolled. They were then divided into two groups. In group 1, 25 pregnant women were supplemented with 800mg of calcium and 250 IU of vitamin D for 6 weeks. Group 2, women were supplemented with 800mg of calcium for 6 weeks only. Baseline and 6 weeks after supplementation serum calcium and vitamin D levels were measured in both groups. Baseline values of serum calcium and plasma vitamin D were not significantly different between group 1 and 2. But after 6 weeks, serum calcium and plasma vitamin D levels in group 1 was found to be significantly higher than group 2 (p<0.01).As vitamin D supplementation leads to better rise in calcium, so vitamin D supplementation should be given in pregnancy.