国际药学与生命科学研究与发展杂志

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STUDY OF MULTIDRUG RESISTANT (MDR) ISOLATES IN PATIENTS WITH VENTILATOR ASSOCIATED PNEUMONIA (VAP) IN TERTIARY CARE HOSPITAL

Manpreet Kaur, Bhavna Singla, Rubina Malhotra

The identification of microorganisms which cause ventilator associated pneumonia (VAP) is important for formulating appropriate therapies. In this study, we have reported the incidence of VAP and the prevalence of multidrug resistant (MDR) microorganisms from patients who were diagnosed with VAP in our medical-surgical intensive care unit (ICU) during the period from July 2013 to May2014.Material and Methods: Patients who were on mechanical ventilation for more than 48hrs and in whom ventilator associated pneumonia was suspected, when a new and persistent pulmonary infiltrate appeared on the chest radiograph and who had at-least two of the following criteria, were included in the study: 1. Fever ≥38�?�?C or hypothermia ≤36�?�?C 2. WBC count ≥10000/mm3 or ≤4000/mm3 and 3. Purulent endotracheal secretion.Results: The incidence of VAP in our hospital setting was found to be 40% and the most frequently isolated pathogens were Acinetobacter species, Klebsiellapneumoniae, Pseudomonas aeruginosa, E.coli and Staphylococcus aureus. Of the 110 isolates which were studied, 57(51.8%) were found to be MDR.Conclusion: In conclusion, the incidence of VAP and the prevalence of multidrug resistant microorganisms were quite high in our ICU setup. A local surveillance program at each centre is essential, as the knowledge of local resistant patterns is vital for selecting the appropriate agents for treating infections.