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Synthesis of Dihydroimidazole Derivatives under Solvent Free Condition and Their Antibacterial Evaluation
Mahmoud Abd El Aleem Ali Ali El-Remaily, Shaaban K Mohamed, Ahmed MM Soliman, and Hossam Abd el-Ghanya
Reaction of 2-guanidinobenzoxazole with several halogenated active methylene compounds has revealed formation of the corresponding dihydroimidazole derivatives under solvent free conditions in excellent yield. The anti-bacterial evaluation of the newly synthesized products against different types of Gram-positive and Gramnegative bacteria was performed. Most of products showed high inhibitory effect. The structure of all compounds has been characterized by on IR, 1H-NMR, 13C-NMR, Mass spectrum and some X-ray diffractions.
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