生物化学与生理学：开放获取

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The Biochemistry of Hunger Stimulating Hormone: Why Understanding This Cascade In Hypothalamus Is Beneficial

Mahjabin Rashid, Md. Shariful Islam, M Salahuddin, Md. Sayfullah, Deluwer Hossain, MA Momin, M. Abu Sayed, Jay Prakash Sah and Sanjay Kumar Shah

Ghrelin is the key hormone responsible for our hunger stimulate to food intake in body system. At present a huge number of people suffer from obesity, so understanding the mechanisms by which various hormones and neurotransmitters have influence on energy balance has been a subject of current research in neuroscience. At present ghrelin is the only known gastrointestinal hormone that increases food intake where Plasma ghrelin levels are inversely correlated with body weight and rise following weight loss in humans. It is a natural ligand of the growth hormone (GH) secretagogue (GHS) receptor type 1a (GHS-R1a). The GHS-R is highly expressed in the hypothalamus, but is also found in the brainstem, pituitary, GI tract, adipose tissue and other peripheral tissues. Ghrelin is still recognized as a potential drug target for weight regulation. The main objective of this is to summarize the current knowledge and optimize about the physiology and pathophysiology of ghrelin in food intake regulation.