国际药学与生命科学研究与发展杂志

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THE NEW ADVANCEMENT NANOTECHNOLOGY: PRONIOSOMES AS A PROMISING AND POTENTIAL DRUG CARRIER

Rishikesh Gupta, Santosh Kumar, Nikhil Gupta , Anurag Kumar

The advance in nanotechnology (NDDS) which helps in preparing newer formulations.One of the advancement in nanotechnology is the preparation of ‘Proniosome derived’ niosomes. Approaches to stabilize niosomal drug delivery system without affecting its properties of merits have resulted in the development of the promising drug carrier, proniosome.These proniosomes minimize or reduces problems of niosomes associated with physical stability such as aggregation,fusion,leakage problems and provide additional convenience intransportation, distribution, storage and dosing.The review article provides an insight about these approaches along with a novel vesicular approach known as proniosomes. This new emerging concept has demonstrated the potential in improving the oral bioavailability, targeting drugs to the specific target site and also permeation of drugs across the stratum corneum(skin). It prolongs the existence of the drug in systemic circulation(blood circulation) and finally reduces the toxicity. The goal of this study is to introduce and explore proniosomes as a carrier system for various pharmaceutical and cosmeceutical applications.